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The surgeon typically removes: The head of the pancreas The duodenum (the first part of the small intestine) The gallbladder The lower portion of the bile duct Sometimes a portion of the stomach (in the classic Whipple) or the lower stomach is preserved (in the pylorus-preserving variant) Regional lymph nodes The surgeon then reconstructs the digestive tract by connecting the remaining pancreas, bile duct, and stomach to the small intestine, so that pancreatic juice, bile, and food can again flow into the digestive system

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Brain tissue is particularly vulnerable to NAD+ depletion due to its high energy demands and limited regenerative capacity, with neurons requiring constant NAD+ availability for energy production, DNA repair, and stress responses